One health
Communicable diseases remain one of the major causes of mortality worldwide. There are disparities in the numbers of individuals affected by disease between low-and-middle-income countries and those in developed nations. Microbes will play in important role in drug discovery: producing anticancer drugs and antimicrobials. Applying One Health principles, to understand the interaction of pathogens and the human host, development of diagnostics, treatments, and disease prevention, applied microbiologists can shape global health and wellbeing outcomes.
News
Evolutionary model for antibiotic resistance reveals dose timing critical to care
The study that uses a “fitness seascape” to incorporate a patient’s dosage schedule into models that predict whether an infection will develop antibiotic resistance has found that inconsistent timing and missing early doses can lead to treatment failure.
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NewsOxymatrine, a quinoline alkaloid derived from Sophora flavescens, inhibits the Malassezia biofilm
Oxymatrine not only controls Malassezia overgrowth but also manages psoriasis symptoms, offering a dual-action mechanism for safer and more effective therapy, a new study shows.
NewsScientists develop a treatment platform to disable the ‘biofilm’ shield of superbugs
Researchers have developed a platform that utilizes microbubbles to deliver gene-targeted nanoparticles capable of breaking down MRSA biofilms, offering an innovative solution for treating infections resistant to conventional antibiotics.
NewsResearchers identify new llama-derived antibodies against current and future coronaviruses
Scientists have discovered a unique class of small antibodies that are strongly protective against a wide range of SARS coronaviruses, including SARS-CoV-1 and numerous early and recent SARS-CoV-2 variants.
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News
Fusobacterium nucleatum in colorectal cancer: Ally mechanism and targeted therapy strategies
A recent review systematically outlines the pathogenic mechanisms of Fusobacterium nucleatum in colorectal cancer and summarizes both current and emerging strategies for its therapeutic targeting.
NewsGeneXpert MTB/RIF technology can distinguish non-tuberculous mycobacterial infection
Xpert Mycobacterium tuberculosis/rifampicin (Xpert MTB/RIF) in alveolar lavage fluid can not only detect rifampicin resistance but also distinguish pulmonary tuberculosis (TB) from non-tuberculosis mycobacterial (NTM) pulmonary disease.
NewsEpidemiological trends and serological profiles of respiratory pathogens in Guangzhou
A new study analyzing the epidemiological trends of multiple respiratory pathogens in Guangzhou, China, from 2013 to 2023, indicates the need for age- and gender-specific approaches to infection prevention and management.
NewsProbiotic breakthrough: Bifidobacterium animalis subsp. Lactis A6 shows promise in alleviating comorbid constipation and depression
A new study clarifies how gut microbes influence mental health and offers a safe, targeted probiotic therapy, Bifidobacterium animalis subsp. Lactis A6 (BBA6), for comorbid constipation and depression.
NewsCan a psychedelic compound from mushrooms benefit people with cancer and major depression?
New results from a clinical trial reveal that a single dose of psilocybin—a naturally occurring psychedelic compound found in mushrooms—can provide sustained reductions in depression and anxiety in individuals with cancer suffering from major depressive disorder.
NewsVaccinated patients hospitalized with COVID-linked acute kidney injury less likely to need dialysis after discharge
Vaccinated patients hospitalized with COVID-19 who developed acute kidney injury had better outcomes than unvaccinated patients with the same condition, new research suggests. The study found vaccinated patients were less likely to stay on dialysis after discharge, and more likely to survive, than unvaccinated patients.
NewsWhen bacteria get hungry, they kill – and eat – their neighbors
Scientists have discovered a gruesome microbial survival strategy: when food is scarce, some bacteria kill and consume their neighbors. The researchers show that under nutrient-limited conditions, bacteria use a specialized weapon — the Type VI Secretion System (T6SS) — to attack, kill, and slowly absorb nutrients from other bacterial cells.
News Ribosome profiling identifies thousands of new viral protein-coding sequences
With the help of a technique called Massively Parallel Ribosome Profiling (MPRP), scientists have identified more than 4000 open reading frames (ORFs) across 679 human-associated viral genomes.
NewsAn oral cholera vaccination campaign aims to reach more than 2.6 million people in Sudan’s Khartoum State
A 10-day reactive oral cholera vaccination campaign, launched on 10 June in 5 localities in Sudan’s Khartoum State, aims to protect more than 2.6 million people aged 1 year and above from cholera infection, interrupt transmission and help contain the cholera outbreak.
News2 million Americans with hepatitis C at risk if Supreme Court cancels free preventative care, study finds
A ruling overturning the Affordable Care Act (ACA) coverage mandate has the potential to dramatically change the landscape for early detection and treatment of hepatitis C virus in the U.S., according to a new paper.
NewsA combination of exercise and omega-3 reduces the severity of tooth root infections
Rats that exercised and took fatty acid supplements responded better to bacteria and the inflammatory process of apical periodontitis, which can occur when caries reach the root canal and cause an infection.
NewsIs your gut microbiome a calorie ‘super harvester’?
A little-known microbe makes methane in your gut — and may help you get more calories from food, according to a new study. Researchers found that people whose gut microbiomes produce a lot of methane are especially good at unlocking extra energy from a high-fiber diet.
NewsPeople with inflammatory RMD tolerate zoster vaccine well, study finds
New work presented at the 2025 annual EULAR congress in Barcelona focuses on the recombinant zoster vaccine (RZV), which contains recombinant glycoprotein E – the major target of CD4+T-cells. The abstract describes the tolerability and safety of RZV in patients with inflammatory rheumatic and musculoskeletal diseases (iRMD).
NewsGeographic bias in virus naming: Lessons from coronavirus show it’s better to act early
A new study highlights the need to avoid geographically-based naming right from the outset of a pandemic. It analyzes the impact of the WHO’s introduction of the Covid nomenclature based on Greek letters - Alpha, Beta, Delta, etc.
NewsStudy indicates that severe forms of COVID-19 infection in children may increase cardiovascular disease risks
Scientists analysed blood samples from 147 children across different COVID-19 conditions and identified significant metabolic disruptions beyond the acute viral infection phase. These alterations affect how the body processes fats (triglycerides and cholesterol) critical to healthy heart structure.
NewsNew research reveals how bacteria export the building blocks of biofilms
Chemists examined how the polysaccharide “Pel” – a central component of many biofilms – is exported out of the cell by the pathogen P. aeruginosa and describe the structure of the so-called PelBC export complex, which represents the last station in the cell before “Pel” is released.
NewsCultured mini-organs reveal the weapons of aggressive Shigella bacteria
Thanks to lab-grown miniature intestines, researchers have successfully mapped how aggressive Shigella bacteria infect the human gut. The study opens the door to using cultured human mini-organs to investigate a wide range of other serious infections.
NewsHPV drives tumor development in rare nasal cancers
Human papillomavirus (HPV) can drive tumor development in some rare sinonasal squamous cell carcinomas (SNSCCs), according to a new comprehensive study of these tumors from investigators who also identified common mutations among these cancers and a potential combination treatment.
NewsScholars take a new look at controversial Stateville prison malaria research 75 years ago
Medical ethicists are shining a light on a buried part of the malaria research conducted on inmates at Illinois’ Stateville Penitentiary 75 years ago.